If you're going to have tiles that are 80x32, you'll still have to break them up into individual 16x16 tiles if you want to use the properly on a scene with a 16x16 grid.
You can still select a group of tiles to place at once by dragging the mouse to create a rectangle (when selecting tiles) of all the tiles you want to place.
You will get weird visual errors when placing tiles that don't match the grid size of the scene. I suspect this is the case...