How big are your screens? If I were you I would turn on the "see screen bounds" in your build screen and turn on the grid and then take a look. Each box within the player area is 32 pixels if you are using regular sized art. Chances are that most of what you are going to use in your game will be a box, or two, or three. That means most of your art won't be bigger than 96 x 96 (3 boxes x 3 boxes). Once you import it you can change the collision shapes to make it exact. If you want art that will look good on a big screen, do everything 4x as big and set your import settings to 4x.