No smoothing is best for pixelart. In that case, pixels are scaled up and down to keep their shapes (i.e. squares). Bicubic is best for small games when you are scaling up to higher resolution. For instance, with your 480x320 game scaling up to 1334x750 iphone 6, you would want it to scale with bicubic.
From my experience, the best graphics come from making your game 1x at a high resolution (such as 2048x1536 for ipads) and bilinear scaling down to the other resolutions. I never use 4x, 3x, 2x, or 1.5x because it saves multiple copies of the images and can make your file size massive. I think it should be defaulted to just 1x because I don't think people utilize the other scales properly, anyway. The first thing I do with any game is uncheck the other scales in settings.
Now there is caveat to what I was just saying. With pixel art, a lot of times black lines will appear on the screen. This is simply because the system is looking for data and the chances are that your actor pixels do not perfectly match. When this happens, a black line appears at the edge of the picture that did not scale. I have not played around with settings enough to figure out how to get rid of that.
Long story short, the best resolution is large images and large game screen scaled down with no smoothing (for pixelart) or bilinear for other art.