As we know, indexing an image can reduce the image file-size (losslessly) if you just index and set the colour pallet to only use the amount of colours the image has. While this is known to save on filesizes, does it also help with RAM usage?
Here's a tileset in both indexed, and normal colour counts.

It's easily possible to do this with GIMP in seconds. So if this actually shaves off RAM usage, I may actually look into this trick, then.